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Zero3™ Animal Trials

TriAgenics has conducted extensive animal testing (live animal and ex vivo bench-level tissue testing) with the goal of demonstrating safety and efficacy of its Zero3 TBA (3rd molar Tooth Bud Ablation) technology. Extensive live animal testing starting in 2015 has demonstrated the ability to successfully perform the 3TBA procedure. TriAgenics Zero3 technology has been engineered to control all aspects of the Zero3 TBA process. As demonstrated in multiple animal studies, Zero3 TBA permanently blocks complete molar agenesis. Additional live animal studies have been completed to optimize the thermal ablation process to minimize collateral tissue damage outside the tooth bud. The menu items below provide a representative overview of TriAgenics’ animal testing program.

The following CT image time series show a sagittal (lateral) view of an unablated maxillary control molar tooth bud (upper left quadrant) and the resulting progression of tooth formation inside the molar tooth bud starting at age 8 weeks (pig animal model) to a nearly fully formed crown at age 24 weeks.

The following CT image time series show a sagittal (lateral) view of an ablated mandibular molar tooth bud (lower left quadrant) at age 8 weeks (pig animal model) and the resulting post operative healing response through to age 24 weeks (16 weeks post op)

Pro Forma Website

This is a pro forma website based solely upon animal study data. TriAgenics’ Zero3™ 3TBA procedure is not approved for human use.